Displaying episodes 1 - 30 of 58 in total

An Introduction and Some Definitions

This is a podcast about the biggest explosion in biological knowledge in human history and it is has been happening all around us over the last 30 years. The Genomics ...

Genetics Before Genomes

How genes first came to be described, then connected to the proteins they usually encode and eventually to two methods for sequencing DNA, the stuff of genes.

The Power of an Idea - The Human Genome Project

The beginnings of the genomics revolution came with a bold proposal to sequence the entire genetic material, the genome, of a human being. It was very much the geneti...

Two Ways to Solve a Genomics Jigsaw Puzzle

How do we determine the sequence of a DNA molecule that might be hundreds of thousands to millions of base pairs in size? Not all at one time. In this episode, we wi...

The First Cellular Genome, Part 1

1995 marks the beginning of the true genomics era as the first genome of a cellular organism was published. The shotgun sequencing approach proved to be successful. ...

The First Cellular Genome - Part 2

The first genome sequence of a cellular organism was published in 1995. In this episode, we see what a sequence call tell us about the biology of an organism.

Introduction to a Survey of Genomes - Agrobacterium tumefaciens C58

Now we will tour through a survey of some sequenced genomes. All three domains of life will be represented, but the Bacteria and Archaea will get the lion’s share. F...

Survey of Genomes - Entomopathogenic Xenorhabdus strains

Brad jumps in with 2 pathogens of insect larvae that do their dirty work in collaboration with tiny soil roundworms that carry the bacteria in their gut. Together, th...

Survey of Genomes - Thermoplasma acidophilum

In this episode from the survey of genomes, Nikkia Schady from 2019 Hiram College Genetics course and the Women’s Volleyball team will introduce us to a member of the ...

Survey of Genomes - Treponema pallidum

In this episode from a survey of genomes, Daijah Sek from the 2019 Hiram College Genetics course walks us through the genome of the syphilis pathogen Treponema pallidum.

Survey of Genomes - Drosophila melanogaster

In this episode from the survey of genomes, Kaitlyn Morse from the 2019 Hiram College Genetics course moves us into the world of eukaryotic genomes. Her focus is on t...

Survey of Genomes - Schizosaccharomyces pombe

In this episode from the survey of genomes, Brett Bentkowski from the 2019 Hiram College Genetics course introduces us to the unicellular eukaryote Schizosaccharomyces...

Survey of Genomes - Caulobacter crescentus

Tim Stucky takes us away from the human microbiome out into nature, specifically clean freshwater habitats with very few nutrients. He discusses the genome of Cauloba...

Survey of Genomes - Pseudomonas aeruginosa

A grape jelly smell and greenish blue pigments in an open wound are a sure sign of a serious infection that is hard to cure. Kiara Jeffrey from the 2019 Hiram College...

Survey of Genomes - Rickettsia prowazekii

What do lice, flying squirrels, and World War I have in common? That weird question is answered by Jake Lininger from the 2019 Hiram College Genetics course as he intr...

Survey of Genomes - Clostridium perfringens

Being at the wrong place at the wrong time can sometimes mean trouble and that is exactly what happens when a particular soil bacterium gets into a wound. Ashley Redm...

Survey of Genomes - Yersinia pestis strain KIM

In this episode from the survey of genomes, Alexis Polcawich from the 2019 Hiram College Genetics course talks about Yersinia pestis, the microbe behind one of the dea...

Survey of Genomes - Campylobacter jejuni

Ka Shing Allan So from the 2019 Hiram College Genetics course introduces us to the largest bacterial cause of food-related gastrointestinal infections - Campylobacter ...

Survey of Genomes - 2 Bifidobacterium Strains

Time to talk about a good guy bacterium in the human gut! Stephanie Cipa from the 2019 Hiram College Genetics course tells the fascinating story of the bacterial genu...

Survey of Genomes - Aeropyrum pernix K1

There are 3-5 major groups within the Domain Archaea. One of those is called the Crenarcheota and Brayla Stokes from the 2019 Hiram College Genetics course tells us a...

Survey of Genomes - Ralstonia solanacearum

Bacterial pathogens don’t just attack humans and other animals. There are many important bacterial pathogens of plants and Sam Hitchcock, working with just his “off h...

Survey of Genomes - Mycobacterium tuberculosis

Consumption, phthisis (pronounced ti-a-sis), lung fever, and the white plague are just some of the names used over the centuries for a disease that still infects upwar...

Survey of Genomes - Vibrio cholerae strain El Tor N16961

In this episode from a survey of genomes, Danielle Vincent from the 2019 Hiram College Genetics course will introduce us to Vibrio cholerae El Tor N16961 and what its ...

Survey of Genomes - E. coli O157:H7

In this episode from the survey of genomes, Taylor Yamamoto from the 2019 Hiram College Genetics course discusses the genome of E. coli O157:H7, not a microbe you want...

Survey of Genomes - Halobacterium NRC-1

Zoe Ceballos introduces us to a member of the Domain Archaea that lives in a very extreme habitat - salt at saturating concentration (> 5 molar). Halobacterium and...

Survey of Genomes - Methanococcus jannaschii

The first group of Archaea were methanogens - microbes that produce methane as a byproduct of their metabolism. The first ever Archaea genome sequenced was from the m...

An Interlude on Pathogen Genomes

Brad jumps in amongst the Survey of Genomes to speak to the question of “why do we need to sequence the genome of a pathogen we just want to kill?”

I Don’t Think It Means What You Think It Means

Brad puts the dreaded “P-word” (Prokaryote) to rest and introduces the Archaea, the 3rd domain of life only recognized as distinct in 1977.

The True Extreme Athletes - Extremophiles

Brad jumps back in to comment on the extreme lifestyles seen in some microbes.

Survey of Genomes - Chlorobium tepidum TLS

Look out your window at that beautiful tree or shrub nearby. Now imagine it living in a hot springs at over 50C doing photosynthesis without oxygen as a byproduct but...